The human parasite, Toxoplasma gondii, is paralyzed without two components of the apical polar ring - PubMed
3 hours ago
- #Toxoplasma gondii
- #parasite motility
- #apical polar ring
- The apical polar ring is a conserved structure in apicomplexan parasites that anchors microtubules.
- Two components, APR9 and KinesinA, are crucial for Toxoplasma gondii motility; loss of both paralyzes the parasite.
- Paralysis from the double knockout leads to impaired invasion, egress, and lytic cycle.
- Cellular defects include abnormal actin accumulation, impaired conoid extension, and reduced adhesin secretion.
- The study highlights the apical polar ring's role in motility and subcellular processes in Toxoplasma gondii.