Structural determinants of beta-cell failure in type 2 diabetes: a multimodality imaging study - PubMed
3 days ago
- #pancreatic-imaging
- #type-2-diabetes
- #beta-cell-mass
- Small pancreas volume and high intrapancreatic fat deposition (IPFD) are associated with reduced beta-cell mass.
- Reduced beta-cell mass correlates with lower insulin secretion, measured via HOMA2-%B.
- Individuals with a small, high-fat pancreas have the highest risk of type 2 diabetes (T2D), as shown in cross-sectional and longitudinal studies.
- Longitudinal data confirmed a significantly increased hazard ratio (3.12) for T2D in those with small/high-fat pancreas compared to other groups.
- The study supports a structural phenotype linking pancreatic size and fat content to beta-cell failure and T2D risk.