Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE): A Protocol for a Pre-Planned Sub-Study of a Randomized Clinical Tri
3 hours ago
- #cardiac arrest
- #clinical trial protocol
- #acute kidney injury
- Acute kidney injury is common after cardiac arrest, affecting over 30% of resuscitated patients and 10% needing kidney replacement therapy.
- The STEPCARE-MAKE sub-study evaluates the effects of sedation depth, fever management, and blood pressure targets on major adverse kidney events.
- It's part of the randomized STEPCARE trial with a factorial design, involving 3500 patients across three intervention sets.
- Primary outcome is MAKE, combining death within 30 days, kidney replacement therapy initiation, or persistent renal dysfunction.
- Secondary outcomes include changes in creatinine levels from baseline across various hospital time points.