Dual Antiplatelet Therapy and Immediate Intensive Statin in Mild Ischemic Stroke: A Randomized Trial - PubMed
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- #statin
- #antiplatelet therapy
- #ischemic stroke
- The study investigated the effect of combining clopidogrel-aspirin and immediate intensive statin in patients with acute mild ischemic stroke or TIA.
- A multicenter, randomized trial with 6,100 patients used a 2-by-2 factorial design across 222 hospitals in China.
- Primary outcome was new stroke within 90 days; clopidogrel-aspirin plus delayed statin showed significant reduction (HR 0.69).
- Safety outcome was moderate-to-severe bleeding; clopidogrel-aspirin groups had a low but increased risk compared to aspirin alone.
- Combination therapy with clopidogrel-aspirin and delayed statin was superior to aspirin plus delayed statin, driven mainly by clopidogrel-aspirin.