KLF6 activation marks an angiogenic and apoptosis resistant endothelial phenotype in pulmonary arterial hypertension - PubMed
3 hours ago
- #KLF6
- #pulmonary arterial hypertension
- #angiogenesis
- KLF6 expression is elevated in pulmonary arterial hypertension (PAH) and promotes endothelial repair and angiogenesis.
- KLF6 activation results in transcriptomic remodeling distinct from KLF2 and KLF4, contributing to an angiogenic and apoptosis-resistant endothelial phenotype.
- Elevated KLF6 is found in endothelial cells, progenitor cells, and alveolar capillary dysplasia-associated PAH, linking it to vascular pathology.
- KLF6 stimulates vascular smooth muscle cell proliferation, which can be attenuated by drugs bosentan and imatinib.
- KLF6 activation orchestrates endothelial repair and is a key feature of the angio-proliferative vascular phenotype in PAH.