RNA-binding protein RCAN1.1L modulates ATF2 mRNA stability to promote mitochondrial fission in acute ischemic stroke - PubMed
2 hours ago
- #RNA-binding protein
- #mitochondrial fission
- #ischemic stroke
- Plasma RCAN1.1 levels are significantly elevated in acute ischemic stroke (AIS) patients.
- Mitochondrial translocation of RCAN1.1L in the ischemic penumbra worsens cerebral infarction by promoting mitochondrial fission and neuronal apoptosis.
- RCAN1.1L stabilizes ATF2 mRNA by binding to its 3'-UTR (nucleotides 2915-2935), leading to accumulation of mitochondrial ATF2 (mtATF2) protein.
- MtATF2 upregulates FIS1 protein, enhancing mitochondrial fission and driving intrinsic apoptosis.
- The RNA aptamer R1SR13 competitively binds to RCAN1.1L, disrupting the RCAN1.1L-mtATF2-FIS1 axis and exerting neuroprotective effects, highlighting its therapeutic potential.