Non-24-Hour Sleep-Wake Disorder in Children and Adolescents: A Case Series - PubMed
3 hours ago
- #Circadian Rhythm
- #Neurodevelopmental Disorders
- #Schronodisruption
- The article presents a case series of six sighted children with Non-24-Hour Sleep-Wake Disorder (N24SWD), highlighting their clinical characteristics and treatment outcomes.
- All children had free-running sleep cycles ranging from 24 to 29 hours and were diagnosed with neurodevelopmental disorders, including autism spectrum disorder, ADHD, and anxiety disorders.
- Treatment with melatonin, bright light therapy, and behavioral interventions showed variable success, but long-term entrainment was difficult due to side effects, poor adherence, and family burden.
- Some families opted for flexible, free-running schedules, which led to improved mood and functioning by accommodating natural sleep patterns.
- The study suggests that pediatric N24SWD management should be individualized and family-centered, with a need for better diagnostic tools and long-term therapeutic strategies.