Epigenetic alterations in cancer metastasis: molecular mechanisms and implications for precision oncology - PubMed
2 days ago
- #precision oncology
- #epigenetics
- #cancer metastasis
- Metastasis, the cause of most cancer deaths, involves epigenetic reprogramming, not just genetic changes.
- Epigenetic mechanisms like DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs regulate gene expression in metastasis stages such as EMT and colonization.
- These epigenetic changes interact with EMT pathways to influence cellular plasticity, resistance to cell death (anoikis), and adaptation to new environments.
- Epigenetic alterations, including DNA methylation patterns and miRNA dysregulation, serve as potential diagnostic and prognostic biomarkers for cancer.
- Understanding epigenetic regulation in metastasis can lead to biomarkers and targeted therapies for precision oncology.