Blood and brain tissue RNA transcriptomics reveal six potential targets of Parkinson's disease: a meta-analysis - PubMed
4 hours ago
- #Meta-Analysis
- #Parkinson's Disease
- #RNA Transcriptomics
- Largest human tissue meta-analysis for Parkinson's disease (PD) with 47 blood and brain datasets.
- Identified 19 potential PD targets: 13 in blood, 6 in brain, including 6 dysregulated in both tissues.
- Blood DEGs involved in immune regulation; brain DEGs linked to apoptosis and cell growth/proliferation.
- Separate analysis by cell type (e.g., leukocytes) and brain region reduced variability and revealed specific targets.
- RNA-seq datasets showed lower variability than microarrays (p<0.01), aiding reliable target identification.