GPR84 blockade in macrophages mitigates sepsis-induced liver injury via PPARα-driven metabolic reprogramming and M2 polarization - PubMed
3 hours ago
- #Sepsis liver injury
- #GPR84
- #Macrophage polarization
- GPR84 blockade in macrophages reduces sepsis-induced liver injury.
- The protective mechanism involves PPARα-driven metabolic reprogramming.
- GPR84 inhibition shifts macrophage phenotype from inflammatory M1 to anti-inflammatory M2.
- PPARα activation is restored via the cAMP-PKA-CREB signaling pathway, enhancing mitochondrial fatty acid oxidation.
- In Pparα-deficient mice, the benefits of GPR84 blockade are lost, confirming its essential role.