SREBP1 Transactivation of NHE3 Impairs Cardiac Contraction and Aggravates Heart Failure - PubMed
3 hours ago
- #Heart Failure
- #NHE3
- #SREBP1
- SREBP1 activation in human and mouse hearts with HFrEF, independent of metabolic conditions, impairs cardiac contractility.
- SREBP1 directly regulates NHE3 expression, leading to increased activity, which disrupts cardiomyocyte ion handling (Na+ and Ca2+ overload).
- Genetic modulation of SREBP1 or NHE3 in mice rescues calcium dysregulation and improves heart function, suggesting therapeutic potential.