Schizantherin B alleviates cisplatin-induced ototoxicity and does not interfere cisplatin-based chemotherapy in a breast cancer model - PubMed
3 days ago
- #Schizantherin B
- #cancer therapy
- #otoprotection
- Schizantherin B (SNB) from Schisandra chinensis shows potential in preventing cisplatin-induced hearing loss (CIHL) without reducing its anticancer efficacy.
- SNB protected hair cells, cochlear spiral ganglion cells, and ribbon synapses in ex vivo studies and restored hearing responses close to normal levels in vivo.
- In tumor cell lines and a breast cancer mouse model, SNB did not interfere with cisplatin's ability to reduce tumor mass.
- The protective mechanism of SNB involves reducing oxidative stress and apoptosis in auditory cells via the Bcl-2/Bax/cleaved-Caspase-3 signaling pathway.