A single centre retrospective study of the long‑term weight and pregnancy-related outcomes in women of reproductive age before and after liraglutide exposure - PubMed
3 hours ago
- #weight regain
- #liraglutide
- #pregnancy outcomes
- The study is a retrospective analysis of 556 women of reproductive age treated with liraglutide for obesity, with 97 (17.4%) conceiving after exposure.
- Women who conceived had a mean final weight change of +1.1% after 2-5 years, while non-conceiving women lost -6.7%, indicating weight regain post-liraglutide in those who became pregnant.
- No significant differences were found in gestational weight gain or adverse pregnancy outcomes (e.g., gestational diabetes, c-section rates, preterm delivery) between pregnancies before and after liraglutide exposure.
- Subgroup analysis suggested lower gestational weight gain with metformin use during pregnancy, but this was not statistically significant.
- All women who conceived had inconsistent obesity medication use during the study period, compared to 36.5% of non-conceiving women.
- The conclusion states that preconception liraglutide exposure, when discontinued before pregnancy, is linked to weight regain but not increased gestational risks, though sample size limitations are noted.