Gabapentinoid Use and Risk of Alzheimer's Disease-Related Dementias: A Systematic Review and Meta-analysis of Observational Studies - PubMed
3 hours ago
- #Meta-analysis
- #Gabapentinoids
- #Dementia Risk
- Gabapentinoid use (gabapentin and pregabalin) is associated with modestly higher estimated odds of Alzheimer's disease-related dementias (ADRD).
- The pooled odds ratio from observational studies is 1.28, indicating an association, but high heterogeneity and residual confounding limit causal inference.
- The association appears weaker in studies with a lower risk of bias and is moderated by study population age.
- Certainty of the evidence is rated as low, emphasizing the need for cautious prescribing and further prospective research.