Associations of estimated glucose disposal rate and overactive bladder and the potential mediating role of systemic inflammation: NHANES 2005-2018 - PubMed
3 hours ago
- #overactive bladder
- #inflammatory biomarkers
- #insulin resistance
- eGDR (estimated glucose disposal rate) is a marker of insulin resistance (IR) linked to overactive bladder (OAB).
- Higher eGDR correlates with reduced OAB risk (OR=0.89 per unit increase, 48% lower risk in highest quartile).
- The association between eGDR and OAB is inverse and nonlinear.
- Systemic inflammation mediates a small portion (0.64-3.15%) of the eGDR-OAB link.
- Other mechanisms like autonomic dysfunction likely play a larger role.
- Study uses NHANES 2005-2018 data, involving over 31,000 participants.