Predictive Role of PSA Kinetics in Oncological Outcomes of Metastatic Castration-sensitive Prostate Cancer - PubMed
2 hours ago
- #metastatic castration-sensitive prostate cancer
- #androgen receptor signaling inhibitor
- #PSA kinetics
- PSA kinetics, including PSA nadir ≤0.02 ng/ml, PSA response rate ≥99%, and time to PSA nadir (TTN) >3 months, are strong independent prognostic factors for improved oncological outcomes in high-risk mCSPC.
- The study retrospectively analyzed 352 high-risk mCSPC patients from the ULTRA-J database treated with upfront ARSI doublet therapy, linking PSA metrics to castration-resistant prostate cancer-free survival (CRPC-FS) and overall survival (OS).
- Multivariate analysis identified PSA nadir >0.02 ng/ml, PSA response rate <99%, and TTN ≤3 months as predictors of shorter CRPC-FS and OS, suggesting these biomarkers can guide treatment intensification or closer monitoring in clinical practice.