Dietary Protein Reduction During Isocaloric Conditions Reduces Body Weight in Men With Overweight or Obesity - PubMed
3 hours ago
- #FGF21
- #Weight Loss
- #Dietary Protein
- Reducing dietary protein intake from 1.8 g/kg to 0.9 g/kg per day, while substituting with increased carbohydrates, led to weight loss of approximately 2.0 kg in men with overweight or obesity over 5 weeks, without restricting total calorie intake.
- Protein reduction increased plasma levels of fibroblast growth factor 21 (FGF21), and changes in FGF21 concentration were inversely correlated with changes in body weight, suggesting a potential role for FGF21 in mediating the weight loss effect.
- Fat mass decreased significantly, while lean body mass only showed a tendency to decrease, indicating that the weight loss was primarily driven by a reduction in fat mass rather than muscle mass.
- Despite the increase in FGF21, key components of its receptor complex (FGFR1 and β-klotho) and downstream targets in subcutaneous adipose tissue remained unchanged, as did markers of skeletal muscle mitochondrial oxidative phosphorylation.