iMSC-derived extracellular vesicles and their miRNA cargo influence inflammation and oxidative damage in an in vitro osteoarthritis model - PubMed
3 hours ago
- #extracellular vesicles
- #miRNA therapy
- #osteoarthritis
- Osteoarthritis (OA) is a chronic joint disease marked by cartilage degradation and inflammation with no effective cure.
- Mesenchymal stromal cells (MSCs) from induced pluripotent stem cells (iMSCs) offer a standardized alternative to traditional MSCs.
- Extracellular vesicles (EVs) from iMSCs (iEVs) are studied as a cell-free therapy for OA, focusing on their miRNA cargo.
- Six specific miRNAs (hsa-miR-17-5p, -20a-5p, -21-5p, -29a-3p, -29b-3p, -29c-3p) mediate anti-inflammatory and antioxidant effects.
- In an in vitro OA model, iEV treatment reduced pro-inflammatory cytokines, ROS accumulation, and oxidative damage while restoring antioxidant defenses.
- The findings highlight iMSC-derived EVs as a promising, minimally invasive therapeutic strategy for OA by modulating inflammation and oxidative stress.