Prion-based protein self-assembly tunes mutagenesis to enable rapid adaptation - PubMed
2 hours ago
- #mutagenesis
- #prion
- #adaptation
- Prion-based protein self-assembly acts as a mutagenesis switch, enabling rapid adaptation in yeast populations.
- This mechanism alters DNA repair and recombination proteins in Saccharomyces cerevisiae, benefiting short-term evolution under strong selective pressure.
- In Candida albicans, a prion regulator accelerates the emergence of fluconazole resistance, suggesting conserved adaptive utility.
- Protein self-assembly provides epigenetic memory that tunes genome diversification over generations while maintaining resilience to genotoxic stress.