Hyperglycemia aggravates vitiligo through succinate/SUCNR1-mediated T cell activation - PubMed
2 hours ago
- #vitiligo mechanism
- #succinate SUCNR1
- #hyperglycemia
- Hyperglycemia accelerates vitiligo progression, revealed through a case-control study and mouse model.
- Succinate was identified as key in worsening vitiligo, activating CD8+ T cells via SUCNR1.
- Succinate also increases keratinocyte secretion of CXCL9 and CXCL10 by stabilizing HIF-1α, aiding T cell skin-homing.