Association and prognostic value of adiposity distribution indices for all-cause mortality in cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide study - PubMed
3 hours ago
- #CKM syndrome
- #mortality prediction
- #adiposity distribution
- The study evaluated the prognostic value of adiposity distribution indices for all-cause mortality in individuals with early to intermediate cardiovascular-kidney-metabolic syndrome (CKM) stages (0-3).
- Using data from NHANES (1999-2006) with mortality follow-up through 2019, 5907 adults were analyzed, and 11 adiposity indices were assessed via machine learning algorithms.
- Four indices indicating peripheral-to-central adiposity predominance (TCWR, CWR, AWR, SWR) were consistently identified as key predictors, with higher levels linked to lower all-cause mortality.
- TCWR and CWR showed linear inverse trends, while AWR and SWR had nonlinear threshold effects; associations persisted across BMI subgroups and were robust in sensitivity analyses.
- A combined index model improved discriminative ability (AUC = 0.769) compared to single indices and conventional BMI-based models, offering higher net clinical benefit.
- The findings suggest these indices are strong mortality predictors in CKM stages 0-3, providing prognostic information beyond BMI for early risk stratification.