Cortical development dynamics across autism spectrum disorder mouse models - PubMed
3 hours ago
- #autism spectrum disorder
- #cortical development
- #single-nucleus sequencing
- ASD mouse models show common neurobiological processes despite genetic diversity.
- Radial glial cell lineage perturbations are a key convergence point, reflecting transient developmental delays.
- Largest transcriptional differences in early postnatal neurons involve downregulation of synaptic and ion channel genes.
- Molecular convergence across models is stage-specific and diminishes by postnatal day 14.
- Electrophysiological changes include altered neuronal excitability and synaptic properties with model-specific nuances.
- Sex-specific effects observed, with female mice often showing larger gene expression changes.