Decoding neuroinflammation: the critical role of NLRP3 inflammasome in Alzheimer's disease - PubMed
3 hours ago
- #Alzheimer's disease
- #neuroinflammation
- #NLRP3 inflammasome
- NLRP3 inflammasome is a key molecular mediator linking immunological activation and neurological pathology in Alzheimer's disease.
- Activation of NLRP3 is triggered by factors like oxidative stress, amyloid-β, mitochondrial dysfunction, and gut dysbiosis, leading to the release of pro-inflammatory cytokines IL-1β and IL-18.
- The review explores both canonical and noncanonical pyroptosis pathways and the involvement of glial cells, particularly microglia and astrocytes, in NLRP3-mediated neuroinflammation.
- NLRP3 activation is modulated by signaling pathways such as NF-κB, TLR4, TREM2, purinergic, and MAP4K6, which intensify inflammatory responses in Alzheimer's.
- Preclinical and clinical research targets NLRP3 and its regulators with potential treatments including Simufilam, MCC950, OLT1177, and CY-09, highlighting therapeutic potential for anti-inflammatory strategies.