Lifespan normative modeling of brain microstructure - PubMed
2 hours ago
- #neuroimaging
- #normative modeling
- #white matter
- Presents a large-scale normative model for white matter microstructure using diffusion MRI data from 54,583 individuals aged 4–91 years.
- Uses hierarchical Bayesian regression to derive lifespan trajectories and centile curves for regional diffusion tensor imaging metrics, accounting for age and sex.
- Demonstrates the model's utility by detecting and visualizing microstructural deviations in mild cognitive impairment, Alzheimer's disease, and 22q11.2 deletion syndrome.
- Provides a publicly available reference tool for identifying and comparing brain abnormalities across disorders and in individual cases.
- Based on standardized analysis and quality control across 19 international datasets, with potential for adaptation to future data.