A PI(3,5)P2/CHMP4B axis on lysosomes is essential for microautophagic degradation of STING - PubMed
2 hours ago
- #lysosomal microautophagy
- #PI(3,5)P2/CHMP4B axis
- #STING degradation
- STING, a key player in type I interferon responses, is terminated via ESCRT-driven lysosomal microautophagy.
- The phosphoinositide PI(3,5)P2 and CHMP4B on lysosomes are essential for encapsulating STING during microautophagy.
- CHMP4B directly binds to PI(3,5)P2, and its recruitment to membranes depends on PI(3,5)P2 presence.
- A CHMP4B mutant unable to bind PI(3,5)P2 fails to support STING degradation and signaling resolution.