The metabolomic signatures mediate associations between physical frailty and metabolic dysfunction-associated steatotic liver disease - PubMed
2 hours ago
- #frailty
- #MASLD
- #metabolomics
- Physical frailty is linked to an increased risk of metabolic dysfunction-associated steatotic liver disease (MASLD), especially worsening the impact of metabolic syndrome on MASLD incidence.
- Mendelian randomization supports a causal effect of physical frailty on MASLD, but not the reverse, indicating frailty may precede and contribute to liver disease development.
- Metabolomic analysis reveals shared plasma metabolite signatures between frailty and MASLD, with fatty acids and triglyceride-rich lipoproteins partially mediating their association.
- Frailty screening could help identify high-risk individuals for early MASLD prevention, particularly in those with metabolic syndrome, though further studies are needed for confirmation.