Lactate-driven H3K18 lactylation promotes cisplatin resistance in bladder cancer via HNRNPF-Parkin mediated mitophagy - PubMed
4 hours ago
- #Cisplatin resistance
- #Bladder cancer
- #Mitophagy
- Lactate-driven histone H3K18 lactylation (H3K18la) promotes cisplatin resistance in bladder cancer.
- H3K18la activates HNRNPF, which interacts with Parkin to enhance mitophagy via VDAC1 ubiquitination.
- Targeting the H3K18la-HNRNPF-Parkin axis may overcome cisplatin resistance in bladder cancer.