Bioelectric Reawakening by a Self-Powered Thermoelectric Hydrogel Accelerates Diabetic Ulcer Repair - PubMed
2 hours ago
- #thermoelectric hydrogel
- #diabetic wound healing
- #self-powered bioelectricity
- A self-powered thermoelectric hydrogel generates microcurrents using the skin-air temperature gradient to restore bioelectric cues in diabetic foot ulcers (DFU).
- The hydrogel incorporates luteolin and Zn2+ for antibacterial, antioxidant, and anti-inflammatory effects, remodeling the hostile wound microenvironment.
- It demonstrates strong wet adhesion and mechanical stability, with thermoelectric stimulation activating Ca2+/calmodulin-dependent PI3K/Akt and Erk signaling in fibroblasts.
- In vitro, the hydrogel shows broad-spectrum antibacterial activity, immunomodulation, and pro-angiogenic capacity, accelerating wound healing by 66.84% in diabetic rats.
- This strategy integrates bioelectric restoration with microenvironment remodeling for DFU repair without external power input.