Longitudinal Change in Blood-Based Biomarkers and the Association With MRI-Measured Neurodegeneration in Cognitively Unimpaired Individuals - PubMed
3 hours ago
- #Alzheimer's disease
- #blood biomarkers
- #neurodegeneration
- Blood biomarkers like GFAP, pTau217, and NfL show associations with MRI-measured brain atrophy in cognitively unimpaired individuals.
- Baseline GFAP levels and their increases correlate with widespread atrophy across Alzheimer's disease signature brain regions.
- pTau217 baseline is linked to atrophy in medial temporal areas, with changes in pTau217 preceding hippocampal atrophy by about 20 years.
- GFAP indicates broader neurodegeneration, while pTau217 is more specific to medial temporal regions.
- The study supports using blood biomarkers for early identification and monitoring in Alzheimer's disease prevention and clinical care.