Extracellular Vesicles in Regenerative Dentistry - PubMed
3 hours ago
- #regenerative dentistry
- #extracellular vesicles
- #tissue engineering
- Extracellular vesicles (EVs) are nanoparticles that carry biomolecules and serve as key paracrine regulators in tissue regeneration, offering a cell-free alternative to cell transplantation.
- EVs from various cell types can promote regenerative processes like M2 macrophage polarization, neurogenesis, angiogenesis, and odonto-osteogenesis, but may also cause inflammation and tissue damage depending on their source.
- EVs play a critical role in dental applications, including periodontal and dental pulp regeneration, osseointegration, and craniomaxillofacial bone repair, with lncRNAs and microRNAs influencing outcomes via specific signaling pathways.
- Biomaterials and engineered EVs enhance EV delivery and efficacy, and human studies show promising clinical results, such as improved periodontal and alveolar bone regeneration.
- Clinical translation is limited by EV heterogeneity, cargo variability, and manufacturing challenges, requiring standardized optimization and scalable production methods for future progress.