Interplay Between the Ketogenic Diet and the Gut Microbiome in Glioblastoma: A Comprehensive Review of Mechanisms and Clinical Implications - PubMed
4 hours ago
- #Ketogenic Diet
- #Glioblastoma
- #Gut Microbiome
- Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis and median survival under one year.
- Standard treatments like surgery, radiotherapy, and temozolomide are costly and reduce quality of life, increasing interest in adjunctive therapies.
- The ketogenic diet (KD) targets GBM's metabolic vulnerabilities by limiting glucose, which tumor cells depend on, and exploiting their limited ketone metabolism.
- Despite promise in other conditions, KD's effectiveness in GBM shows inconsistent results due to small trials, low adherence, and varied study designs.
- Gut microbiome (GM) variability is emerging as a key factor, influencing KD efficacy and tumor progression, with distinct GM profiles found in glioma patients.
- This review explores the interplay between KD and GM in GBM, emphasizing how GM affects metabolic outcomes to reconcile inconsistencies and personalize treatments.