Gut microbiota-modulating interventions in paediatric type 1 diabetes: a systematic review and meta-analysis - PubMed
3 hours ago
- #gut microbiota
- #meta-analysis
- #type 1 diabetes
- Gut microbiota-modulating interventions may improve glycaemic control in children and adolescents with type 1 diabetes, particularly reducing glycated haemoglobin and fasting blood glucose.
- The meta-analysis included 12 randomized controlled trials with 808 pediatric participants, but evidence was limited by clinical and methodological heterogeneity.
- No significant effects were found for total daily insulin dose or C-peptide levels, and specific recommendations on formulation, dose, or duration cannot be made.
- Immune-inflammatory, microbiota-related, and intestinal permeability outcomes suggested possible benefits, but reporting was inconsistent and not suitable for pooled analysis.
- Larger, well-designed pediatric trials are needed to establish efficacy and safety of these interventions for type 1 diabetes management.