Single-nucleus profiling reveals a core disease signature and cell type-specific vulnerabilities in early Rett syndrome - PubMed
3 hours ago
- #single-nucleus RNA-seq
- #neural circuits
- #Rett syndrome
- Single-nucleus RNA sequencing identifies a core disease signature in MeCP2- cells across Rett syndrome models.
- Non-cell autonomous effects are found exclusively in female MeCP2+ excitatory neurons in mosaic RTT environments.
- An underappreciated MeCP2- interneuron subtype shows the most transcriptional dysregulation in both male and female RTT hippocampi.
- The study highlights distinct vulnerabilities in excitatory and inhibitory circuits between mosaic and nonmosaic RTT environments.