Impact of BECLIN1 haploinsufficiency on goblet cell function and susceptibility to colitis - PubMed
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- #colitis
- #autophagy
- BECLIN1 haploinsufficiency in intestinal epithelium leads to subtle structural defects without spontaneous inflammation.
- Partial BECLIN1 loss causes goblet cell dysfunction, reduced mucin production, and mucus barrier vulnerability in the colon.
- Under DSS challenge, BECLIN1 insufficiency exacerbates colitis severity, indicating increased susceptibility to inflammatory stress.