A Two-sample Mendelian Randomization Study of Air Pollution/Smoking and Cardiac ArrestAdherence to a Low-Risk, Healthy Lifestyle and Risk of Sudden Cardiac Death among WomenSmoking, Smoking Cessation,
3 days ago
- #Cardiac Arrest
- #Mendelian Randomization
- #Smoking
- This Mendelian randomization study investigates the causal link between air pollution/smoking and cardiac arrest, finding smoking significantly increases cardiac arrest risk (OR=2.182, p=0.019).
- No significant causal associations were detected between air pollution metrics and cardiac arrest, though caution is advised due to limited statistical power for modest effects.
- The study utilized GWAS summary data and multiple MR methods (IVW, MR-Egger, etc.), with sensitivity analyses indicating no horizontal pleiotropy or outliers.