Disrupted endocannabinoid signaling contributes to systemic inflammation in acute pancreatitis - PubMed
3 hours ago
- #systemic inflammation
- #endocannabinoids
- #acute pancreatitis
- Endocannabinoid signaling disruption worsens systemic inflammation in acute pancreatitis.
- Circulating 2-AG levels decrease with disease severity in both patients and mouse models.
- Restoring 2-AG reduces inflammation, modulates macrophages, and mitigates lung injury.
- Both CB1 and CB2 receptors play distinct roles in regulating inflammatory responses.
- Endocannabinoid system presents a promising therapeutic target for acute pancreatitis complications.