Role of the Post-translational ISGylation of Interferon Regulatory Factor 9 in Diabetes-Induced Podocyte Injury - PubMed
3 hours ago
- #ISGylation
- #Podocyte Injury
- #Diabetic Kidney Disease
- IRF9 transcriptional activity increases in podocytes of diabetic kidney disease (DKD) patients.
- IRF9 protein expression rises under high glucose without mRNA changes, linked to worse kidney function.
- IRF9 promotes podocyte injury via inflammasome activation and pyroptosis.
- High glucose upregulates ISG15, which ISGylates IRF9, inhibiting its ubiquitination and enhancing stability.
- Deleting IRF9 or knocking down ISG15 in podocytes reduces injury in diabetic mice; overexpression worsens it.
- Targeting the ISG15-IRF9 axis may offer a new therapy for DKD-related podocyte injury.