Treatment of Early-Onset Specified and Unspecified Bipolar Disorders: A Systematic Review and Strategies for Identifying and Managing a Thermally Dysregulated Subtype in Children - PubMed
2 days ago
- #systematic review
- #bipolar disorder
- #pediatric psychiatry
- Early-onset bipolar disorder (BD) includes non-classic presentations categorized as specified or unspecified BD (S-USBD), with a focus on the temperature and sleep dysregulation disorder (TSDD) subtype.
- Systematic review identified 11 family-focused psychotherapy studies, mostly RCTs, showing positive outcomes compared to treatment-as-usual for S-USBD subtypes.
- Only three psychopharmacological RCTs were found, with only one on aripiprazole showing significant benefit over placebo in high-risk children with S-USBD.
- Limited separate outcome data exists for S-USBD subtypes, except for two case series on TSDD, which reported promising results with lithium, clonidine, ketamine, and cooling measures.
- Family-focused psychotherapy is recommended as an adjunctive treatment, while pharmacological approaches for S-USBD lack robust research, necessitating further controlled trials.