Ultra-rapid cryo-EM data acquisition method enabled by continuous recording based beam image shift - PubMed
3 hours ago
- #data acquisition
- #cryo-electron microscopy
- #continuous recording
- Developed a new cryo-EM data acquisition method called Continuous Recording Beam-Image Shift (CR-BIS) to eliminate camera-induced delay time.
- Enables ultra-rapid data collection: ~34,000 micrographs in single-particle analysis mode and ~1,000 tilt series in cryo-electron tomography mode per 24 hours.
- Maintains data quality in 3D reconstructions for both single-particle and tomographic datasets.
- Broadly applicable as it integrates into existing acquisition software via scripting without hardware modifications.
- Patent granted in China (ZL202510925138.0) and pending in the US and Europe, with some authors listed as inventors.