Recurrence in the chemotherapy regimen of bladder carcinoma originates from quiescent epidermoid-like cells - PubMed
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- #tumor relapse
- #bladder carcinoma
- #chemotherapy resistance
- Bladder cancer relapse after chemotherapy is driven by quiescent epidermoid-like cells that survive treatment.
- Using CRISPR/Cas9 lineage tracing and single-cell RNA sequencing in mice, the study tracks tumor evolution with and without chemotherapy.
- Epidermoid-like cells exit quiescence to cause relapse, forming distinct tumors via evolutionary routes involving specific transcriptional changes.
- Plasticity of epidermoid-like cells and changes in plasticity during evolution determine the phenotypes of relapsed tumors.
- Insulin-like growth factor-binding protein 5 (IGFBP5) is identified as a key regulator of aggressive progression and squamous features in bladder carcinoma.
- Blocking IGFBP5 expression reduces chemoresistance and malignant behaviors in relapsed tumors, suggesting a potential therapeutic approach.