The ligand preference of LRP1 is regulated by O-glycans - PubMed
4 hours ago
- #O-glycosylation
- #neurodegenerative diseases
- #LRP1
- LRP1's ligand preference is regulated by O-glycans on linker regions.
- GALNT11 is the primary enzyme that initiates O-glycan modifications on LRP1 linkers.
- O-glycans influence LRP1 uptake of specific ligands, notably increasing tau uptake and decreasing amyloid-β uptake.
- Incomplete sialic acid capping on O-glycans allows inter- and intramolecular interactions, as shown by MD simulations.
- These findings suggest a regulatory mechanism for endocytic receptors with implications for neurodegenerative diseases.