The impact of caffeine consumption on migraine: a systematic review - PubMed
an hour ago
- #caffeine
- #migraine
- #systematic review
- Caffeine consumption's impact on migraine varies: genetic predisposition to higher intake may reduce migraine risk, especially for migraines with aura.
- Acute excessive intake (≥3 drinks/day) or abrupt withdrawal can trigger migraine attacks in some individuals.
- Habitual moderate caffeine use generally does not increase average migraine burden, according to observational studies.
- Mendelian Randomization studies suggest lifelong genetic liability to caffeine intake is associated with a reduced risk (OR 0.53-0.71).
- More large-scale prospective cohorts and carefully designed MR studies are needed to confirm findings and clarify precise impacts.