Effects of Semaglutide on Body Composition and GFR: A Prespecified Analysis of the SMART Trial - PubMed
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- Semaglutide treatment for 24 weeks reduced lean body mass and fat mass in adults with CKD and overweight or obesity.
- Changes in lean body mass or fat mass did not correlate with changes in creatinine or cystatin C‑eGFR or measured GFR.
- Semaglutide significantly reduced extracellular water and BP, with changes in BP correlating with extracellular water changes.