Engineered Nestin+ TSPC-Derived Exosomes Promote Tendon Repair Via Metabolic Reprogramming - PubMed
4 hours ago
- #exosomes
- #tendon repair
- #metabolic reprogramming
- Engineered exosomes from Nestin-overexpressing tendon stem/progenitor cells (Nes-EVs) enhance tendon repair in mouse models.
- Nes-EVs reduce cellular senescence, promote tenogenic differentiation, and improve mitochondrial function in tenocytes.
- Mechanistically, Nes-EVs enrich pantothenate and CoA biosynthesis, boosting ATP production and reducing oxidative stress.
- The study suggests Nes-EVs as a promising acellular therapy for tendinopathy by reprogramming cellular metabolism.