CD4+ T cells promote fibrosis during metabolic dysfunction-associated steatohepatitis - PubMed
3 days ago
- #CD4+ T cells
- #Liver Fibrosis
- #MASH
- CD4+ T cells undergo a shift towards Th1, regulatory, and cytotoxic phenotypes in both murine and human metabolic dysfunction-associated steatohepatitis (MASH).
- Hepatic CD4+ T cells in MASH show increased effector activity and proinflammatory cytokine secretion, amplifying inflammation.
- The OX40-OX40L axis forms a feed-forward activation loop between CD4+ T cells and myeloid cells, driving MASH progression.
- Blocking the OX40-OX40L axis reverses liver pathology in mice and reduces disease markers in a human ex vivo model.
- Genetic depletion or inhibition of CD4+ T cells attenuates fibrosis and decreases monocyte-derived macrophage infiltration.