Influence of an AQP4 haplotype and sleep duration on early Alzheimer's disease - PubMed
3 hours ago
- #Sleep Duration
- #Genetic Variation
- #Alzheimer's Disease
- AQP4 genetic variation did not show an overall association with amyloid-beta or tau burden in the study.
- In participants under 60, minor allele carriers of AQP4 had lower regional tau burden compared to homozygote majors.
- AQP4 modified the link between short sleep (≤6 hours) and medial temporal tau: minor allele carriers with short sleep had higher tau, while homozygote majors showed the opposite.
- The findings suggest AQP4 may influence early tau accumulation and susceptibility to sleep-related Alzheimer's pathology.
- The study involved 450 dementia-free participants from the Framingham Heart Study, using self-reported sleep and PET imaging for biomarkers.