20S proteasome-regulated proteostasis in ELVAs is critical for oocyte-to-embryo transition and female fertility - PubMed
3 hours ago
- #oocyte quality
- #female fertility
- #proteostasis
- Programmed degradation of maternal proteins is essential for oocyte-to-embryo transition.
- PSMA7-deficiency disrupts 20S proteasomes and ELVAs translocation, causing ubiquitinated protein accumulation.
- Maternal Psma7 deletion leads to female infertility with impaired oocyte maturation and early embryo arrest.
- Reduced proteasome abundance and dysfunctional ELVAs in aged oocytes explain declining developmental competence.