Beyond weight loss: How metabolism in human adipocytes is shaped by GLP-1R agonists and dual GIPR/GLP-1R agonists - PubMed
3 hours ago
- #obesity treatment
- #adipocyte metabolism
- #GLP-1R agonists
- Obesity is a chronic disease with rising global prevalence and multiple comorbidities, including type 2 diabetes, cardiovascular disease, and cancers.
- GLP-1 receptor agonists (GLP-1RAs) and dual GIPR/GLP-1R agonists like tirzepatide show significant weight loss benefits and pleiotropic effects on cardiovascular, nervous, and gastrointestinal systems.
- The molecular mechanisms of these agonists in adipose tissue, particularly in human adipocytes, are not fully understood, with most studies relying on animal models.
- Future research should prioritize human-derived adipocyte models to better understand the pathophysiological and pharmacological effects of GLP-1 and GIP agonists in humans.