Loss of cold shock domain-containing protein E1 (CSDE1) function enhances mRNA stability of interleukin-6 and promotes malignant transformation in endometrial cancer cells - PubMed
3 hours ago
- #endometrial cancer
- #CSDE1
- #IL-6 signaling
- CSDE1 is frequently mutated and downregulated in endometrial cancer (EC) tissues.
- Loss of CSDE1 enhances EC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT).
- CSDE1 normally binds to IL-6 mRNA to reduce its stability; losing CSDE1 increases IL-6 expression.
- Silencing IL-6 or using the IL-6 inhibitor Siltuximab reverses the aggressive effects of CSDE1 loss.
- The study identifies CSDE1 as a tumor suppressor in EC and highlights IL-6 signaling as a therapeutic target.