Longitudinal multiphoton imaging of cerebral amyloid angiopathy in response to anti-ApoE4 immunotherapy in mice - PubMed
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- #Cerebral Amyloid Angiopathy
- #Multiphoton Imaging
- #ApoE4 Immunotherapy
- Anti-ApoE4 immunotherapy (HAE-4) reduces overall Aβ plaque area in mice models of cerebral amyloid angiopathy (CAA).
- Vascular fibrillar Aβ deposits increased over time regardless of treatment, with no improvement in vascular function observed in cortical arterioles.
- The treatment did not cause hemorrhagic events, potentially offering an advantage over anti-Aβ immunotherapies in terms of safety.
- Significant immune cell activation was noted in response to HAE-4 treatment without evidence of treatment-related hemorrhages.
- In mice without cranial windows, HAE-4 treatment reduced both plaques and CAA, consistent with previous findings on its efficacy.